Bone Tumours

Bone Tumours

Primary Bone Tumours

Synovial chondromatosis Table 108.1: WHO classification of bone tumours. Introduction Bone tumours in childhood cause considerable anxiety to both the affected child and the parents. They may present with vague symptoms or a fracture and can easily be confused with osteomyelitis or some tumour-like lesions that may be developmental in origin. Benign lesions account for 50% of all bone lesions; ...

Cytological diagnosis of bone tumours.

We evaluated the diagnostic accuracy of fine-needle aspiration biopsy in a prospective study of 300 patients with previously undiagnosed bone lesions. Patients with suspected local recurrence of a primary bone tumour or a metastatic lesion of a previously diagnosed malignancy were excluded. Fine-needle aspiration biopsy was performed under radiological control as an outpatient procedure. The se...

Alkaline Phosphatase in Bone Tumours

Many tissues contain enzymes which will hydrolyse the organic phosphorus compounds to give free phosphoric acid. These enzymes are known as phosphatases. Some of these phosphatases are most active in an alkaline medium and the others in an acid medium. The phosphatase of bone (Yamane, 1931), bile (King and Armstrong, 1934) and white blood cells (Roche, 1931) are alkaline phosphatases, while tho...

Tumours of the Temporal Bone

NF2 gene – Chr 22 VHL (Von Hippel Lindau) disease – Chr 3p Ionizing radiation Criteria for radiation induced temporal bone tumours by LUSTIG is as follows : 1. • The second neoplasm must develop in the irradiated field. 2. • A latent period of at least several years must elapse between radiation exposure and the development of a second primary. 3. • The previous condition must show histological...